作者报告3例肝功正常,在用丙戊酸钠治疗时引起高氨血症的成年患者.其中男性2例,女性1例.3例均为局限性癫痫伴有全身强直一阵挛性发作,联合应用了苯妥英钠、苯巴比妥和丙戊酸钠等药物.后者的用量为750-2000毫克/日.高氨血症的主要表现是:1.体重减轻、恶心、呕吐、厌食等消化道症状;2.脑病的表现:如嗜睡、扑翼样震颤、构音困难、眼球震颤、共济失调等; The authors report 3 patients with normal liver function, adult patients with hyperammonemia when treated with sodium valproate, including 2 males and 1 females, all with localized epilepsy associated with generalized tonic-clonic seizures, Joint use of phenytoin sodium, phenobarbital and sodium valproate and other drugs, which the amount of 750-2000 mg / day. The main performance of hyperammonemia are: 1. Weight loss, nausea, vomiting, anorexia, etc. Gastrointestinal symptoms; 2 encephalopathy performance: such as drowsiness, flapping wing tremor, dysarthria, nystagmus, ataxia;