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目的:探讨雷公藤多苷联合激素治疗儿童紫癜性肾炎(HSPN)的临床疗效及对凝血功能的影响。方法 :将74例HSPN患儿随机分为两组,对照组(37例)采用泼尼松治疗,治疗组(37例)采用泼尼松联合雷公藤多苷治疗。比较分析两组的临床疗效、凝血功能及不良反应。结果 :观察组的总有效率为86.5%,显著高于对照组64.9%(P<0.05);观察组和对照组激素疗程分别为(21.5±4.2)d,(39.2±5.7)d,差异有统计学意义(P<0.05)。治疗后,两组的凝血功能指标均有所改善,而观察组APTT、PT、FIB及DD与对照组比较,差异有统计学意义(P<0.05)。观察组的不良反应较对照组轻。结论 :雷公藤多苷联合激素治疗儿童HSPN安全有效,可缩短激素使用疗程,降低高凝状态,不良反应少。
Objective: To investigate the clinical efficacy of tripterygium glycosides combined with hormonal treatment of children with purpura nephritis (HSPN) and its effect on coagulation function. Methods: 74 children with HSPN were randomly divided into two groups. The control group (37 cases) was treated with prednisone. The treatment group (37 cases) was treated with prednisone combined with tripterygium glycosides. The clinical efficacy, coagulation function and adverse reactions of the two groups were compared and analyzed. Results: The total effective rate in the observation group was 86.5%, which was significantly higher than that in the control group (64.9%, P <0.05). The hormonal courses in the observation group and the control group were (21.5 ± 4.2) days and (39.2 ± 5.7) days, respectively Statistical significance (P <0.05). After treatment, the indexes of coagulation function in both groups were improved, while the APTT, PT, FIB and DD in the observation group were significantly different from those in the control group (P <0.05). The adverse reaction in the observation group was lighter than that in the control group. Conclusion: Tripterygium glycosides combined with hormonal treatment of children with HSPN safe and effective, can shorten the course of hormone use, reduce hypercoagulable state, fewer adverse reactions.