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目的:观察幽和汤及雷贝拉唑钠肠溶片治疗幽门螺杆菌(Hp)感染的疗效,并进行对比分析,探讨中医、西医治疗HP感染的有效性以及幽和汤是否具备替代抗生素治疗Hp感染的可行性。方法:选取2014年10月~2015年10月陕西中医药大学附属医院收治的87例患者为研究对象,随机均分为3组,分别为治疗组1、治疗组2和对照组。治疗组1:口服幽和汤,每日1剂,分2次服用,每次100ml;治疗组2:口服雷贝拉唑钠肠溶片(10mg/片),每日2次,一次1片。对照组:口服雷贝拉唑钠肠溶片(10mg/片),每日2次,一次1片;盐酸左氧氟沙星片(0.1g/片),每日2次,一次2片;克拉霉素片(0.25g/片),每日2次,一次2片;以上药物疗程均为15天。对比分析3组之间的临床疗效、HP感染根除率。结果:幽和汤治疗组1、雷贝拉唑钠肠溶片治疗组2及三联疗法对照组的Hp根除率分别为31.03%、34.48%、65.52%,幽和汤治疗组1、雷贝拉唑钠肠溶片治疗组2与三联疗法对照组比较,差异均有统计学意义(P<0.05)。治疗前,幽和汤治疗组1、雷贝拉唑钠肠溶片治疗组2及三联疗法对照组三组间症状总积分比较,差异无统计学意义(P>0.05),具有可比性;治疗后幽和汤治疗组1、雷贝拉唑钠肠溶片治疗组2及三联疗法对照组症状总积分均优于治疗前,差异有统计学意义(P<0.05),且幽和汤治疗组1、雷贝拉唑钠肠溶片治疗组2优于三联疗法对照组,组间比较差异有统计学意义(P<0.05)。治疗后幽和汤治疗组1、雷贝拉唑钠肠溶片治疗组2及三联疗法对照组总有效率分别为89.66%、93.10%、62.07%,幽和汤治疗组1、雷贝拉唑钠肠溶片治疗组2总有效率均优于三联疗法对照组,组间比较差异有统计学意义(P<0.05)。结论:治疗组1、治疗组2的Hp根除率均低于对照组;治疗组1、治疗组2总有效率均优于对照组;治疗组1与治疗组2比较无显著差异;幽和汤不具备替代抗生素治疗Hp感染的可行性。
Objective: To observe the efficacy of Youhe Decoction and rabeprazole sodium enteric-coated tablets in the treatment of Helicobacter pylori (Hp) infection, and to compare and analyze the effectiveness of traditional Chinese medicine and Western medicine in treating HP infection and whether Youhe Decoction has alternative antibiotics Feasibility of Hp infection. Methods: A total of 87 patients admitted from Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine from October 2014 to October 2015 were randomly divided into three groups: treatment group 1, treatment group 2 and control group. Treatment group 1: Oral administration of Fu and soup, daily 1, taking 2 times, each 100ml; treatment group 2: oral rabeprazole sodium enteric-coated tablets (10mg / tablets), 2 times a day, . Control group: oral rabeprazole sodium enteric-coated tablets (10mg / tablet), twice a day, once a tablet; levofloxacin tablets (0.1g / tablet) twice daily, two tablets; clarithromycin tablets (0.25g / tablet), 2 times a day, once 2; the above drug treatment are 15 days. The clinical efficacy, HP infection eradication rate were compared between the three groups. Results: The Hp eradication rates of YouHuTang treatment group 1, rabeprazole sodium enteric-coated treatment group 2 and triple therapy control group were 31.03%, 34.48%, 65.52%, YouHuTang treatment group 1, The difference between the two groups was statistically significant (P <0.05). Before treatment, You and Tang treatment group 1, rabeprazole sodium enteric-coated treatment group 2 and triple therapy control group, the total score between the three groups, the difference was not statistically significant (P> 0.05), comparable After you and soup treatment group 1, rabeprazole sodium enteric-coated tablets treatment group 2 and triple therapy control group symptoms were better than before treatment, the difference was statistically significant (P <0.05), and you and the soup treatment group 1, rabeprazole sodium enteric-coated tablets treatment group 2 is better than the triple therapy group, the difference was statistically significant (P <0.05). The total effective rate of the treatment groups of Youhe Decoction 1, rabeprazole sodium enteric-coated tablets treatment group 2 and triple therapy control group were 89.66%, 93.10%, 62.07%, You You Tang treatment group 1, rabeprazole The total effective rate of sodium enteric-coated group 2 was better than that of triple-therapy group, the difference was statistically significant (P <0.05). Conclusion: The Hp eradication rates of treatment group 1 and treatment group 2 are lower than that of the control group. The total effective rate of treatment group 1 and treatment group 2 is better than that of control group. There is no significant difference between treatment group 1 and treatment group 2. Feasibility of not having alternative antibiotics to treat Hp infection.