论文部分内容阅读
用氯丙嗪１０ｍｇ／ｋｇ、５ｍｇ／ｋｇ、２．５ｍｇ／ｋｇ，氯氮平６．６７ｍｇ／ｋｇ、、３．３３ｍｇ／ｋｇ、１．６７ｍｇ／ｋｇ分别对小鼠生殖细胞进行亚急性毒性实验。结果显示：连续给药５天后第１周，两药各剂量组的精子头部畸形率均明显高于阴性对照组，且氯丙嗪的作用强于氯氮平。连续给药５天后第４周，两药各剂量组的精子头部畸形率与阴性对照组无差异，表示停药４周后氯丙嗪及氯氮平对精子的致畸作用已基本消除。睾丸细胞染色体结构畸变率在给药后第１周、第４周检查，均与阴性对照组无差异。提示氯丙嗪及氯氮平对小鼠睾丸生殖细胞染色体结构无明显损伤。
Subacute toxicity experiments were performed on mouse germ cells with chlorpromazine 10 mg / kg, 5 mg / kg, 2.5 mg / kg, clozapine 6.67 mg / kg, 3.33 mg / kg, and 1.67 mg / . The results showed that in the first week after continuous administration for 5 days, the sperm head deformities in each dose group were significantly higher than those in the negative control group, and the effect of chlorpromazine was stronger than clozapine. Four weeks after continuous administration, the teratogenic rate of sperm head in each dose group did not differ from the negative control group, indicating that the teratogenic effects of chlorpromazine and clozapine on sperm were basically eliminated after 4 weeks’ withdrawal. Testicular cell chromosome aberration rate in the first week after administration, the first 4 weeks of examination, were no difference with the negative control group. Tip chlorpromazine and clozapine on the testicular germ cells in mice showed no significant structural damage.