论文部分内容阅读
目的介绍美国上市的造影剂说明书中有关干扰临床检验的关键性信息。方法以美国食品药品监督管理局收录的造影剂说明书为研究对象,检索其中药物干扰临床检验的相关内容。结果美国已上市的造影剂中,钆双胺等6种药物能够干扰临床检验,对检验结果的解释造成不利影响。钆剂可干扰血清中金属离子的测定,而碘普罗胺等碘剂可干扰血液凝血及纤溶系统的检验项目。结论合理安排各种医学检查时间,以减少造影剂对临床检验的干扰。
OBJECTIVE: To introduce the key information pertinent to clinical trials in contrast media listed in the United States. Methods Based on the instructions of the contrast agent contained in the US Food and Drug Administration, the relevant content of the drug interfered with the clinical test was searched. Results Among the listed US contrast agents, six drugs, such as gadodiamide, could interfere with clinical tests, adversely affecting the interpretation of test results. Gadolinium can interfere with the determination of serum metal ions, while iodoprolamine and other iodine can interfere with blood coagulation and fibrinolysis system test items. Conclusion Reasonable arrangements for a variety of medical examination time to reduce the interference of contrast agents on clinical tests.