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目的 :观察甲氰咪胍对恶性梗阻性黄疸病人术后细胞免疫功能的影响 ,探讨其临床应用价值。方法 :将 44例病人随机分为甲氰咪胍治疗组和对照组 ,观察两组间术后感染发生情况 ;用间接免疫荧光法检测T淋巴细胞亚群变化。结果 :治疗组术后感染发生率明显低于对照组 ( 9%对 36 % ,P<0 .0 5 ) ;治疗组术后周围血 CD4+细胞计数、CD4+/ CD8+比值明显高于对照组 ( P<0 .0 5 )。结论 :围手术期应用甲氰咪胍可以改善恶性梗阻性黄疸病人的细胞免疫功能 ,预防术后感染的发生 ,具有临床应用价值
Objective: To observe the effect of cimetidine on postoperative cellular immune function in patients with malignant obstructive jaundice and to explore its clinical value. Methods: Forty - four patients were randomly divided into cimetidine group and control group. The incidence of postoperative infection was observed between the two groups. The changes of T lymphocyte subsets were detected by indirect immunofluorescence assay. Results: The incidence of postoperative infection in the treatment group was significantly lower than that in the control group (9% vs 36%, P <0.05). The CD4 + cell count and CD4 + / CD8 + ratio in the peripheral blood in the treatment group were significantly higher than those in the control group <0 .0 5). Conclusion: Perioperative application of cimetidine can improve cellular immune function in patients with malignant obstructive jaundice and prevent postoperative infection, and has clinical value