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在一组连续100名成人患者中对104只眼做白内障手术,对与年龄有关的白内障病进行研究,使用的方法包括:综合术前评价病人、眼睛和白内障晶体;在手术期间按规定的部位采集白内障标本;用高性能液相色谱法对晶体皮质做生化分析,以及生物统计学资料分析。与从某一供体眼材料提供的人眼清亮晶体的正常值相比较,23Kgamma 晶状体旦白与前轴晶体囊内beta,gamma 和低分子量可溶旦白的总量之比,在统计学上显著低些(P<0.5)。皮质混浊度增加一般与23Kgamma 晶状体旦白的比例进行性降低有关。本组白内障病人虽具有十分不同的与白内障有关的因子,但类似的生化异常提示,与年龄有关的白内障,其进展至少有一部分是有共同途径的。这一点在临床上可有重要意义。
Cataracts were performed on 104 eyes in a series of 100 consecutive adult patients and age-related cataracts were studied using a combination of preoperative evaluation of patients, eyes, and cataract crystals. At scheduled sites during surgery Collecting cataract specimens; using high performance liquid chromatography for biochemical analysis of the crystalline cortex, as well as biostatistical analysis. The ratio of 23K gamma crystallin to the total amount of beta, gamma and low molecular weight soluble denars in the frontal lens capsule, compared to the normal values of the clear eye crystals of a human eye provided from one of the donor ophthalmic materials, is statistically Significantly lower (P <0.5). The increase in cortical turbidity is generally associated with a progressive decrease in the proportion of 23Kgamma lens white matter. Although the group of cataract patients has very different cataract-related factors, similar biochemical abnormalities suggest that age-related cataracts have a common path toward at least some of their progress. This point can be clinically significant.