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通过采用柱层析纯化法测定小檗碱的含量，研究比较了黄连解毒汤的提取工艺流程；采用正交试验法研究了黄连解毒滴丸成型的较优工艺条件：提取物∶ＰＥＧ６０００∶水∶甘油按１∶１．８∶０．４∶０．４比例混匀，保温于（９０±２）℃的滴制装置内，用滴口内径／外径为２．５／３．５（ｍｍ）的滴管以（１０±２）Ｄ／ｍｉｎ的滴速滴入温度为室温的冷却液中。
The content of berberine was determined by column chromatography, and the extraction process of Huanglian Jiedu Decoction was studied and compared. The optimum technological conditions for the formation of Huanglian Jiedu Dripping Pills were studied by orthogonal test: Extract: PEG6000: Water: Glycerol was mixed at a ratio of 1:1.8:0.4:0.4 and kept in a drip device at (90±2)°C. The inner diameter/outer diameter of the mouth was 2.5/3.5 (mm). The dropper was dropped into a cooling liquid at room temperature at a dropping rate of (10 ± 2) D/min.