目的　观察异丙酚用于口腔颌面外科手术麻醉时对循环、呼吸及苏醒的影响，并与传统药物硫喷妥钠相比较。方法　选择颌骨切除手术３０ 例，随机分为两组（异丙酚组和硫喷妥钠组），比较注药前后循环、呼吸等变化。结果　异丙酚对循环的影响比硫喷妥钠小，但呼吸暂停的发生率高于硫喷妥钠（ Ｐ＜ ００１），唤醒时间明显短于硫喷妥钠（ Ｐ＜ ００１）。结论　异丙酚副作用少，苏醒迅速，用于口腔颌面外科等长时间的手术，安全有效。 Objective To observe the effects of propofol on circulation, respiration and wakefulness during oral and maxillofacial surgery anesthesia and to compare with the traditional drug thiopental. Methods Thirty patients with mandibular resection were randomly divided into two groups (propofol group and thiopental group). The changes of circulation and respiration before and after injection were compared. Results Propofol had less effect on circulation than thiopental, but the incidence of apnea was higher than that of thiopental (P <001), and the awake time was significantly shorter than that of thiopental (P <001 ). Conclusion Propofol has few side effects and prompt recovery. It is safe and effective for oral and maxillofacial surgery for a long time.