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目的探讨孕妇人巨细胞病毒（ｈｕｍａｎｃｙｔｏｍｅｇａｌｏｖｉｒｕｓ，ＨＣＭＶ）感染的宫内传播情况以及先天性ＨＣＭＶ感染对胎婴儿的近期影响。方法酶联免疫吸附试验（ＥＬＩＳＡ）筛查孕妇血清ＨＣＭＶ－ＩｇＭ１８８１例，聚合酶链反应（ＰＣＲ）检测血ＨＣＭＶＤＮＡ６５６例；追踪感染孕妇的胎婴儿ＨＣＭＶ感染情况和近期预后。结果孕妇ＨＣＭＶ－ＩｇＭ阳性率为２４％，ＨＣＭＶＤＮＡ阳性率为１２０％，ＨＣＭＶ宫内传播率为１７２％；有畸胎史的孕妇ＨＣＭＶ感染率显著高于无畸胎史者（Ｐ＜００１）；ＨＣＭＶ感染孕妇的胎儿宫内发育迟缓率显著高于非感染孕妇（Ｐ＜００１）；ＨＣＭＶ先天感染儿畸形率、生后发育异常率均显著高于非先天感染儿（Ｐ＜００１）。结论孕妇、胎儿ＨＣＭＶ感染可能导致畸胎、胎婴儿发育异常。
Objective To investigate intrauterine transmission of pregnant women with human cytomegalovirus (HCMV) infection and the recent impact of congenital HCMV infection on infants. Methods 1881 cases of serum HCMV-IgM in pregnant women were screened by enzyme-linked immunosorbent assay (ELISA), and 656 cases of HCMV DNA were detected by polymerase chain reaction (PCR). The HCMV infection status and prognosis of fetus and infants were detected. Results The positive rate of HCMV-IgM in pregnant women was 24%, the positive rate of HCMVDNA was 120%, and the intrauterine transmission rate of HCMV was 172%. The infection rate of HCMV in pregnant women with teratogenic history was significantly higher than that in non-teratogenic history (P <001). The rate of fetal intrauterine growth retardation in HCMV infected pregnant women was significantly higher than that in non-infected pregnant women (P <001). The rate of deformity and postnatal developmental abnormalities in children with HCMV congenital infection were significantly higher than those in non- Infected children (P <0 01). Conclusion Pregnant women and fetus HCMV infection may lead to abnormal development of teratogensis and fetus.