论文部分内容阅读
目的观察海南省新诊断T2DM患者的25羟维生素D[25(OH)D]水平,并探讨25(OH)D与各代谢指标的相关性。方法收集海南省102例新诊断T2DM患者及100名NGT人群的资料。测定FPG、TC、TG、LDL-C、HDL-C、钙(Ca)、磷(P)及血清25(OH)D水平。结果 T2DM组BMI、WC、WHR、SBP、DBP、FPG、TC、TG、LDL-C、Ca高于NGT组(P<0.05),HDL-C及25(OH)D低于NGT组(P<0.05或P<0.01)。相关分析显示,所有受试者25(OH)D水平与HDL-C呈正相关(r=0.149,P<0.05),与WC、WHR、FPG、TC、TG、Ca呈负相关(r=-0.170、-0.201、-0.257、-0.266、-0.431、0.211,P<0.05)。T2DM组25(OH)D水平与TC、TG呈负相关(r=-0.273、-0.483,P<0.05)。NGT组25(OH)D水平与TG呈负相关(r=-0.401,P<0.05)。Logistic回归分析显示,低VitD水平(LD)组患糖尿病风险高于高VitD(HD)组(OR:6.983,P<0.05);中VitD水平(MD)组腹型肥胖风险高于HD水平组(OR:2.271,P<0.05);LD及MD水平组TG增高风险高于HD水平组(OR:5.410、2.964,P<0.05);LD水平组HDL-C降低及血压升高的风险高于HD水平组(OR:3.441、5.690,P<0.05)。结论海南省新诊断T2DM患者VitD水平较NGT人群低;VitD缺乏可能是T2DM及MS发病的危险因素。
Objective To observe the level of 25-hydroxyvitamin D [25 (OH) D] in newly diagnosed T2DM patients in Hainan Province and investigate the relationship between 25 (OH) D and various metabolic parameters. Methods The data of 102 newly diagnosed T2DM patients and 100 NGT patients in Hainan Province were collected. The levels of FPG, TC, TG, LDL-C, HDL-C, calcium, phosphorus and serum 25 (OH) D were measured. Results The levels of BMI, WC, WHR, SBP, DBP, FPG, TC, TG, LDL-C and Ca in T2DM group were significantly higher than those in NGT group (P < 0.05 or P <0.01). Correlation analysis showed that there was a positive correlation between 25 (OH) D level and HDL-C in all subjects (r = 0.149, P <0.05) and negative correlation with WC, WHR, FPG, TC, TG and Ca -0.201, -0.257, -0.266, -0.431, 0.211, P <0.05). The level of 25 (OH) D in T2DM group was negatively correlated with TC and TG (r = -0.273, -0.483, P <0.05). The level of 25 (OH) D in NGT group was negatively correlated with TG (r = -0.401, P <0.05). Logistic regression analysis showed that the risk of diabetes mellitus in patients with low VitD level (LD) was higher than that in patients with high VitD (HD) (OR: 6.983, P <0.05) OR: 2.271, P <0.05). The risk of elevated TG in LD and MD was higher than that in HD (OR: 5.410, 2.964, P <0.05) (OR: 3.441,5.690, P <0.05). Conclusions The serum levels of VitD in newly diagnosed T2DM patients in Hainan Province are lower than those in NGT patients. VitD deficiency may be the risk factor for the pathogenesis of T2DM and MS.