【摘 要】
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For a long period of time,intestinal mesenchymal stromal cells (IMSC) have been considered as a relatively simple and homogeneous group of cells.These cells could effectively regulate intestinal homeostasis and epithelium integrity via producing growth fa
【机 构】
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Department of Immunology and Microbiology,Shanghai Institute of Immunology,Shanghai Jiao Tong Univer
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For a long period of time,intestinal mesenchymal stromal cells (IMSC) have been considered as a relatively simple and homogeneous group of cells.These cells could effectively regulate intestinal homeostasis and epithelium integrity via producing growth factors and cytokines(Powell et al.,2011).With the help of sin-gle-cell transcriptomics studies,it has now been clear that IMSC are quite com-plex and heterogeneous (Kinchen et al.,2018).However,the detailed cellular and molecular mechanisms that regulate the function of these cells remain poorly un-derstood.Therefore,the ability to perturb and evaluate the in vivo function of IMSC is critical to the understanding of intesti-nal stem cell niche and the etiology of the inflammatory bowel diseases as well as colitis-associated colorectal cancer.
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