From Nov. 6 to 10, 2004, a large number of solar events occurred, which triggered many solar flares and coronal mass ejections (CMEs). These CMEs caused two large geomagnetic storms and continuous energy proton events. During this period, one large positive ionospheric storm happened over the East-Asian region on Nov. 8, 2004. On Nov. 10, 2004, a strong spread-F was observed by the ionosonde located in the mid-latitude region of East China and Japan, and the ionospheric fluctuation over the ionosonde stations derived from GPS observation was also obvious. In this report, the characteristics of the spatial distribution of the ionosphere fluctuation and its temporal evolution are studied using the parameter of the rate of total electron content (ROT) derived from dual-frequency GPS measurement. Strong fluctuating activity of the ionosphere was found over the mid-latitude region in the southern and northern hemispheres between longitudes of 100°E and 180°E during the magnetic storm period on Nov. 10, 2004, and a regular movement of the disturbing region was observed. In the end, the reason of the ionospheric fluctuation during this magnetic storm is analyzed. From Nov. 6 to 10, 2004, a large number of solar events occurred, which triggered many solar flares and coronal mass ejections (CMEs). These CMEs caused two large geomagnetic storms and continuous energy proton events. During this period, one large positive ionospheric storm happened over the East-Asian region on Nov. 8, 2004. On Nov. 10, 2004, a strong spread-F was observed by the ionosonde located in the mid-latitude region of East China and Japan, and the ionospheric fluctuation over the ionosonde stations derived from GPS observation was also obvious. In this spatial distribution of the ionosphere fluctuation and its temporal evolution are studied using the parameter of the rate of total electron content (ROT) derived from dual-frequency GPS measurement. Strong fluctuating activity of the ionosphere was found over the mid-latitude region in the southern and northern hemispheres between longitudes of 100 ° E and 180 ° E during the magnetic storm peri od on Nov. 10, 2004, and a regular movement of the disturbing region was observed. In the end, the reason of the ionospheric fluctuation during this magnetic storm is analyzed.