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目的评价国产帕洛诺司琼(吉欧停)预防化疗所致恶心呕吐等不良反应的疗效和安全性。方法随机将接受高致吐风险化疗的患者分为吉欧停组(试验组)及托烷司琼组(对照组),观察两组的急性呕吐、延迟性呕吐及恶心的发生率和毒性反应。结果共入组107例患者,试验组54例,对照组53例;试验组的急性呕吐完全缓解率明显高于对照组(85.2%比67.9%,P<0.05),试验组的延迟性呕吐完全控制率明显高于对照组(68.5%比47.2%,P<0.05),两组的毒性反应发生率相似,未观察到3～4级毒性反应。结论国产帕洛诺司琼预防高致吐风险化疗所致呕吐优于托烷司琼,毒性轻微,值得临床常规应用。
Objective To evaluate the efficacy and safety of domestic palonosetron (Jiou stop) in preventing chemotherapy-induced nausea and vomiting. Methods Patients with high-risk chemotherapy were randomly divided into two groups: geo-stop group (test group) and tropisetron group (control group). The incidences of acute vomiting, delayed vomiting, nausea and toxicity . Results A total of 107 patients were enrolled in the study group, with 54 cases in the test group and 53 cases in the control group. The complete remission rate of acute vomiting in the experimental group was significantly higher than that in the control group (85.2% vs 67.9%, P <0.05) The control rate was significantly higher than that of the control group (68.5% vs 47.2%, P <0.05). The incidence of toxicity was similar between the two groups. Grade 3 to 4 toxicities were not observed. Conclusion Domestic palonosetron is superior to tropisetron in preventing vomiting induced by high risk of vomiting and is less toxic. It is worthy of clinical application.