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目的评价辛伐他汀治疗高脂血症的临床疗效。方法选择高脂血症176例,睡前口服辛伐他汀片20mg,每晚1次,疗程12周,于治疗前及服药后4、12周后各复查血脂、CRP和颈动脉内中膜厚度(IMT),分析其疗效。结果与治疗前相比,各项血脂指标均有明显改善(P<0.05);IMT和CRP较治疗前相比,均具有显著性差异(P<0.05)。结论辛伐他汀降脂疗效确切,且具有较好的调脂外作用,不良反应少,耐受性好,是安全有效的降血脂药物。
Objective To evaluate the clinical efficacy of simvastatin in the treatment of hyperlipidemia. Methods 176 cases of hyperlipidemia were selected, 20 mg of simvastatin tablets were taken orally before going to bed. The courses of treatment were followed up for 12 weeks. The levels of serum lipids, CRP and carotid intima-media thickness (IMT), analyze its curative effect. Results Compared with those before treatment, all the indexes of blood lipid were significantly improved (P <0.05). The IMT and CRP were significantly different from those before treatment (P <0.05). Conclusion Simvastatin is effective in lowering lipid levels and has good lipid-lowering effects with few adverse reactions and good tolerability. It is a safe and effective hypolipidemic drug.