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沉默信息调节因子2相关酶-1(SIRT1)是一种依赖烟碱胺腺嘌呤二核苷酸(NAD+)的第Ⅲ类组蛋白去乙酰化酶,它能去乙酰化修饰组蛋白和非组蛋白底物,从而调控细胞的多种生物学功能。随着研究的增多,SIRT1的功能存在很大争议,SIRT1一方面作为肿瘤促进因子抑制细胞凋亡,促进癌基因的活性,促进肿瘤的发生、发展和转移;另一方面SIRT1作为肿瘤抑制因子,通过调控肿瘤形成过程中异常的炎症信号增加细胞基因组的稳定性,抑制癌基因的活性,从而抑制肿瘤的生成。因此对SIRT1进一步研究的重要性显而易见,以SIRT1为靶点的治疗可能成为肿瘤治疗的新途径。
SIRT1 is a class III histone deacetylase that relies on nicotine amine adenine dinucleotide (NAD +), which can deacetylate histone and non-histone modifications Protein substrate, which regulates a variety of cellular biological functions. With the increase of the research, the function of SIRT1 is very controversial. SIRT1, on the one hand, acts as a tumor-promoting factor to inhibit apoptosis, promote oncogene activity and promote tumorigenesis, development and metastasis; on the other hand, SIRT1 acts as a tumor suppressor factor, By regulating the abnormal signal of inflammation in tumorigenesis, it can increase the stability of cell genome, inhibit the activity of oncogenes and thus inhibit the tumorigenesis. Therefore, the importance of further research on SIRT1 is obvious, the treatment of SIRT1 target may become a new way of cancer treatment.