自提供第一批流感疫苗以来迄今已有30多年,但未能控制住此病流行。追究其原因,主要是流感病毒几乎不断地发生着变异,影响了疫苗效果。本文拟就流感免疫与病毒变异的相互关系,从当前对病毒变异规律的认识中能否获得有效的疫苗,以及国外流感疫苗研究主要设想和现况进行讨论。一、流感病毒的结构与变异流感病毒属正粘液病毒,包括人的甲、 More than 30 years have passed since the first influenza vaccine was provided, but it has failed to contain the epidemic. Investigate its reason, mainly influenza virus occurs almost constantly mutation, affecting the vaccine effect. In this paper, we will discuss the relationship between influenza immunity and virus mutation, whether effective vaccines can be obtained from the current understanding of the law of virus mutation, and the main ideas and status quo of foreign influenza vaccine research. First, the structure and mutation of influenza virus Influenza virus is a positive mucus virus, including human A,