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咖啡因(1、3、7三甲基黄嘌呤)常以治疗早产窒息症。为了研究咖啡因的呼吸兴奋机理,用婴儿重860～1360克,妊娠26—32周,出生后6～75天的8名早产新生儿进行观察。在治疗前及静脉注射咖啡因10毫克/公斤1小时内,用呼吸气速仪罩测量通气量的参数。静脉注射咖啡因10毫克/公斤,表明它能显著地增加呼吸量(VE)(从627±86.5增加到827.7±122.6毫升/分,P<0.005),呼吸频率增加(从66.8±6.1到80.6±10.6次/分,P<0.05),且有增加潮气量(VT)的倾向(9.8±1.4到11.3±2.3毫升)。并成比例地明显降低。呼吸周期时间(TOT)吸气时间(T_1)和呼气时间(T_E)通气量为平均吸入量YT/T_1的结果,是一个中枢呼吸兴备的指标,T_1/T_(TOT)代表时间的影响表明V_E的增加是由于V_T/T_1增加(22.6
Caffeine (1,3,7-trimethylxanthine) is often used to treat preterm asphyxia. In order to study the mechanism of caffeine respiratory excitement, eight preterm newborns weighing 860-1360 g, 26-32 weeks of gestation and 6 to 75 days of age were observed. Before treatment and intravenous injection of caffeine 10 mg / kg within 1 hour, the use of respiratory gas mask measured ventilation parameters. Intravenous injection of caffeine at 10 mg / kg showed that it significantly increased respiration (VE) (627 ± 86.5 to 827.7 ± 122.6 ml / min, P <0.005) and increased respiratory rate (66.8 ± 6.1 to 80.6 ± 10.6 beats / min, P <0.05) with a tendency to increase tidal volume (VT) (9.8 ± 1.4 to 11.3 ± 2.3 mL). And significantly reduced proportionately. TOT The inspiration time (T_1) and expiratory time (T_E) ventilation is the result of the average inhalation volume YT / T_1 and is an index of central respiratory capacity. T_1 / T_ (TOT) represents the influence of time It shows that the increase of V_E is due to the increase of V_T / T_1 (22.6