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目的:了解HER-2在结直肠癌组织中的过度表达率及其与临床病理特点及生存率的相关性。方法:应用免疫组化SP法检测结直肠组织(结直肠癌192例,正常组织102例)HER-2的表达,并进行统计分析。结果:62例(32.3%)结直肠癌标本HER-2过度表达,与正常结直肠组织比较明显升高(P=0.001)。HER-2过度表达与结直肠癌肿瘤分化程度、Duck’s分期相关(P<0.05),HER-2过度表达结直肠癌患者10年生存率较低。结论:结直肠癌组织HER-2过度表达率较正常结直肠组织高,结直肠癌组织中HER-2过度表达提示较差临床预后。
Objective: To investigate the overexpression of HER-2 in colorectal cancer and its relationship with clinicopathological features and survival rate. Methods: Immunohistochemical SP method was used to detect the expression of HER-2 in colorectal cancer tissues (192 cases of colorectal cancer and 102 cases of normal tissues) and statistical analysis. Results: The HER-2 overexpression in 62 (32.3%) colorectal cancer specimens was significantly higher than that in normal colorectal tissues (P = 0.001). The overexpression of HER-2 was associated with Duck’s staging in colorectal cancer (P <0.05). The 10-year survival rate of HER-2 overexpressing colorectal cancer was lower. Conclusion: The overexpression rate of HER-2 in colorectal cancer tissues is higher than that in normal colorectal tissues. Overexpression of HER-2 in colorectal cancer suggests poor clinical prognosis.