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庆大霉素的最佳给药方案应符合临床如下治疗要求:(1)给药后组织和体液迅速达到有效血药浓度;(2)治疗血浓度最适范围为4～8μg/ml;(3)有间歇性血峰冲击;(4)根据细菌受一次冲击后,再生长繁殖需要3～4小时,低于最低有效血浓度的持续时间应不超过4小时.根据以上要求,按病人肾功能正常、体重为50kg(不包括老年人)进行讨论.本文应用的庆大霉素动力学参数:消除速度常数K=0.3小时~(-1);肌肉注射吸收速度常数Ka=2.47小时~(-1);肌肉注射到达最
The optimal dosing regimen of gentamycin should meet the clinical requirements of treatment as follows: (1) the effective plasma concentration of tissue and body fluid is rapidly reached after administration; (2) the optimal range of blood concentration for treatment is 4 ~ 8μg / ml; ( 3) There is intermittent peak blood pressure impact; (4) According to the bacteria by an impact, re-growth and reproduction need 3 to 4 hours, less than the minimum effective blood concentration duration should not exceed 4 hours .According to the above requirements, according to the patient’s kidney Function normal, weighing 50kg (not including the elderly) for discussion.The gentamicin kinetic parameters used in this paper: the elimination rate constant K = 0.3 hours -1; intramuscular absorption rate constant Ka = 2.47 hours ~ ( -1); intramuscular injection reached the most