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目的:评价荆花胃康胶丸对寒热错杂型消化性溃疡(PU)的临床疗效。方法:选取常州市中医医院脾胃病科2016年1月至2018年12月诊治的寒热错杂型PU患者90例，采用随机数字表法分为对照组、观察组各45例。对照组予雷贝拉唑胶囊治疗。观察组患者予荆花胃康胶丸联合雷贝拉唑胶囊治疗。两组疗程均为8周。比较两组胃镜下疗效、主要单项症状疗效、中医证候疗效。结果:观察组胃镜下疗效[临床痊愈42例(93.3%)、显效1例(2.2%)、有效1例(2.2%)]、中医证候疗效[痊愈38例(84.4%)、显效4例(8.9%)、有效2例(4.4%)]均显著优于对照组[胃镜下疗效：临床痊愈35例(77.8%)、显效5例(11.1%)、有效3例(6.7%)，中医证候疗效：痊愈28例(62.2%)、显效6例(13.3%)、有效8例(17.8%)](n Z＝－2.040、－2.463，均n P<0.05)；观察组胃脘灼痛、喜温喜按，口干苦，四肢不温三项单项症状的疗效均显著优于对照组(χn 2＝6.154、6.056、7.174，均n P<0.05)。n 结论:荆花胃康胶丸能促进寒热错杂型PU患者的胃黏膜愈合，改善临床症状，尤其对于缓解胃脘灼痛、喜温喜按，口干苦，四肢不温的症状疗效显著。“,”Objective:To evaluate the clinical effect of Jinghua Weikang capsule in treating peptic ulcer with intermingled heat and cold syndrome.Methods:From January 2016 to December 2018, 90 patients of peptic ulcer with intermingled heat and cold syndrome in Changzhou Hospital of Traditional Chinese Medicine were divided into two groups by the random digital table method, with 45 cases in each group.The control group was treated with rabeprazole capsule, and the observation group were treated with rabeprazole capsule and Jinghua Weikang capsule.The gastroscopic performance, the main individual symptoms and TCM syndrome between the two groups were compared.Results:The gastroscopic performance[42 cases(93.3%) were clinical cured, 1 case(2.2%) was significantly improved, 1 case(2.2%) was improved], TCM syndrome effect[38 cases(84.4%) were clinical cured, 4 cases(8.9%) were significantly improved, 2 cases(4.4%) were improved] in the observation group were significantly better than those in the control group[the gastroscopic performance: 35 cases(77.8%) were clinical cured, 5 cases(11.1%) were significantly improved, 3 cases(6.7%) were improved], TCM syndrome effect: 28 cases(62.2%) were clinical cured, 6 cases(13.3%) were significantly improved, 8 cases(17.8%) were improved](n Z=-2.040, -2.463, all n P<0.05). The improvement of TCM symptoms of epigastric pain which could be relieved by warmth and pressure, dry mouth with bitter taste, cool limbs were significantly better than those in the control group(χn 2=6.154, 6.056, 7.174, all n P<0.05).n Conclusion:Jinghua Weikang capsule can accelerate the repair of gastric mucous of patients with intermingled heat and cold syndrome, improve clinical syndrome, especially these symptoms: stomacha which can be relieved by warmth and pressure, dry mouth with bitter taste, cool limbs.