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鲁拉西酮是一种新型非典型抗精神病药,对多巴胺D2受体、5-HT2A受体及5-HT7受体具有高度亲和力,已经被FDA批准用于治疗成人精神分裂症和双相障碍重性抑郁发作。本文对该药的药理作用、药代动力学、药物相互作用、临床应用、安全性及耐受性进行综述。
Lubratione, a new class of atypical antipsychotics with high affinity for dopamine D2 receptors, 5-HT2A receptors and 5-HT7 receptors, has been approved by the FDA for the treatment of schizophrenia in adults and bipolar disorder Major depressive episode. This article reviews the pharmacological effects, pharmacokinetics, drug interactions, clinical applications, safety and tolerability of this drug.