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用邻苯三酚自氧化法测定了５０例恶性淋巴瘤（ＭＬ）不同病期（初发期、级解期、复发期）、不同病理类型（ＮＨＬ及ＨＤ）、不同临床分期（Ｉ、Ⅱ、Ⅲ、Ⅳ期）病人的红细胞及血浆超氧化物歧化酶＊力变化。结果表明ＭＬ初发及复发病例的红细胞ＳＯＤ活力明显降低，血浆ＳＯＤ活力明显升高（Ｐ均＜０．０１）。缓解期病人红细胞及血浆ＳＯＤ活力大致恢复到正常水平。红细胞与血浆ＳＯＤ活力变化呈负相关（γ＝－０．７１６，ｐ＜０．０１）。比较ＮＨＬ和ＨＤ无论红细胞还是血浆ＳＯＤ活力变化均无显著差异（Ｐ均＞０，０５）。Ⅲ、Ⅳ期病人ＳＯＤ活力变化较Ｉ、Ⅱ期病人明显（Ｐ＜０．０５）。以上结果提示自由基损伤参与了ＭＬ的发生、发展及转归过程，且与病情的严重程度有关。
Fifty cases of malignant lymphoma (ML) were detected by pyrogallol autoxidation at different stages (initial stage, grade and recurrence), different pathological types (NHL and HD), different clinical stages (I, II , Ⅲ, Ⅳ) patients with erythrocytes and plasma superoxide dismutase * force changes. The results showed that erythrocyte SOD activity was significantly decreased and plasma SOD activity was significantly increased in ML patients (P <0.01). In remission, erythrocyte and plasma SOD activity returned to normal levels. Red blood cells and plasma SOD activity was negatively correlated (γ = -0.716, p <0.01). There was no significant difference in SOD activity between red blood cells and plasma in both NHL and HD (P> 0.05). The activities of SOD in stage Ⅲ and stage Ⅳ patients were significantly higher than those in stage Ⅰ and stage Ⅱ patients (P <0.05). These results suggest that free radical injury involved in the occurrence, development and outcome of ML, and the severity of the disease.