采用固体超强酸S_2O_8~(2-)/Fe_2O_3-TiO_2-Nd_2O_3为催化剂,乙酸和乙醇为原料合成乙酸乙酯。考察了酸醇摩尔比、催化剂用量、反应时间、催化剂的重复使用次数对酯化率的影响。实验结果表明:采用此催化剂催化合成乙酸乙酯是可行的,其最佳反应条件为:酸醇摩尔比1:3、催化剂用量1.2g(约为乙酸质量的19.98%)、反应时间1.5h,酯化率在92%以上。该催化剂对设备没有腐蚀性、与产品分离简单、可回收重复使用,是一种新型绿色环保催化剂。 The solid superacid S_2O_8 ~ (2 -) / Fe_2O_3-TiO_2-Nd_2O_3 was used as catalyst to synthesize ethyl acetate from acetic acid and ethanol. The effects of mole ratio of acid to alcohol, amount of catalyst, reaction time and times of repeated use of catalyst on the esterification rate were investigated. The experimental results show that it is feasible to synthesize ethyl acetate using this catalyst. The optimal reaction conditions are as follows: molar ratio of alcohol to alcohol 1: 3, catalyst dosage 1.2g (about 19.98% of acetic acid), reaction time 1.5h, Esterification rate of 92% or more. The catalyst is non-corrosive to the equipment, easy to separate from the product, recyclable and reusable, is a new type of green catalyst.