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目的:分析新疆生产建设兵团医院抗菌药物使用强度(AUD)与鲍曼不动杆菌耐药性变化的相关性,为临床合理用药提供参考依据。方法:回顾性统计2011—2016年该院鲍曼不动杆菌耐药性和抗菌药物的使用情况,采用Pearson和Spearman相关法对AUD与鲍曼不动杆菌耐药性进行相关性分析。结果:2011—2016年共分离出病原菌14 972株,其中鲍曼不动杆菌1 642株,检出率为10.97%;哌拉西林/他唑巴坦及亚胺培南的使用强度与鲍曼不动杆菌的耐药率呈正相关(P≤0.05),其他药物的耐药率与AUD无显著相关性。结论:哌拉西林他唑巴坦及亚胺培南的使用,是导致鲍曼不动杆菌耐药的重要原因之一。
Objective: To analyze the correlation between the strength of antibacterials used in Xinjiang Production and Construction Corps Hospital and the changes of drug resistance of Acinetobacter baumannii, so as to provide a reference for clinical rational drug use. Methods: The clinical data of Acinetobacter baumannii and antibacterials in the hospital from 2011 to 2016 were retrospectively analyzed. The correlation between AUD and Acinetobacter baumannii resistance was analyzed by Pearson and Spearman correlation analysis. Results: A total of 14 972 pathogens were isolated in 2011-2016, of which 1 642 Acinetobacter baumannii strains were detected, the detection rate was 10.97%. The use intensities of piperacillin / tazobactam and imipenem were similar to those of Bowman’s Acinetobacter resistance rate was positively correlated (P≤0.05), other drug resistance rates and AUD no significant correlation. Conclusion: The use of piperacillin / tazobactam and imipenem is one of the important causes of Acinetobacter baumannii resistance.