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目的探讨血浆纤维蛋白原(Fg)与颈动脉粥样硬化的关系。方法选择104例颈动脉粥样硬化性斑块患者,根据斑块性质分为稳定斑块组52例与不稳定斑块组52例;根据颈动脉狭窄程度分为:轻度狭窄组24例、中度狭窄组42例、重度狭窄组38例;同时选取52例健康人群做对照。测定各组Fg水平与颈动脉内中膜厚度(IMT),并进行分析对比。结果不稳定斑块组与稳定斑块组IMT、Fg水平均高于健康对照组(P<0.05或P<0.01);不稳定斑块组IMT、Fg水平高于稳定斑块组(P均<0.05);颈动脉硬化狭窄组IMT、Fg水平均高于健康对照组(P<0.05或P<0.01);各颈动脉硬化狭窄组IMT、Fg水平差异显著(P<0.05),随着狭窄程度越重,IMT及Fg含量越高。结论颈动脉硬化斑块稳定性与狭窄程度均与Fg水平相关,Fg可能通过增加IMT影响颈动脉硬化斑块的稳定性与狭窄程度。
Objective To investigate the relationship between plasma fibrinogen (Fg) and carotid atherosclerosis. Methods A total of 104 patients with carotid atherosclerotic plaques were divided into stable plaque group (n = 52) and unstable plaque group (n = 52) according to the nature of plaque. According to the degree of carotid stenosis, the patients were divided into mild stenosis group (n = 24) 42 cases of moderate stenosis group, severe stenosis group of 38 cases; 52 healthy people at the same time as a control. The level of Fg and carotid intima-media thickness (IMT) in each group were measured and compared. Results The levels of IMT and Fg in unstable plaque group and stable plaque group were higher than those in healthy control group (P <0.05 or P <0.01). The levels of IMT and Fg in unstable plaque group were higher than those in stable plaque group (P < 0.05). The levels of IMT and Fg in carotid atherosclerosis group were higher than those in healthy control group (P <0.05 or P <0.01). There were significant differences in IMT and Fg levels between carotid atherosclerosis group and stenosis group The heavier, IMT and Fg content higher. Conclusion The stability and stenosis degree of carotid plaque are related to Fg level. Fg may affect the stability and stenosis degree of carotid plaque by increasing IMT.