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目的探讨二甲双胍联合去氧孕烯炔雌醇片配合中药组方治疗子宫腺肌病的临床应用疗效。方法 84例子宫腺肌病患者,随机分为西药组和中西药组,各42例。西药组采用二甲双胍联合去氧孕烯炔雌醇片治疗;中西药组采用二甲双胍联合去氧孕烯炔雌醇片配合中药组方治疗。比较两组患者子宫腺肌病治疗总有效率,治疗前后子宫体积、视觉模拟评分法(VAS)评分和月经量,1年受孕率和复发率。结果中西药组患者子宫腺肌病治疗总有效率为95.24%,显著高于西药组的71.43%,差异有统计学意义(P<0.05)。两组患者治疗前子宫体积、VAS评分和月经量比较,差异无统计学意义(P>0.05);中西药组治疗后子宫体积为(132.89±40.71)cm3、VAS评分为(0.45±0.19)分、月经量为(63.28±0.86)ml,低于西药组的(152.03±60.42)cm3、(2.56±0.76)分、(79.88±0.52)ml,差异有统计学意义(P<0.05)。中西药组患者1年受孕率为50.00%,显著高于西药组的23.81%;1年复发率为2.38%,显著低于西药组的14.29%,差异有统计学意义(P<0.05)。结论二甲双胍联合去氧孕烯炔雌醇片配合中药组方治疗子宫腺肌病的临床效果确切,可有效改善患者月经情况和子宫体积,缓解疼痛,提高受孕率,降低复发率,值得推广。
Objective To investigate the clinical effect of metformin combined with ethinyl ethinyl estradiol (DEEG) in treating adenomyosis with traditional Chinese medicine. Methods 84 patients with adenomyosis were randomly divided into western medicine group and western medicine group, with 42 cases in each group. Western medicine group metformin combined with desogestrel ethinyl estradiol tablets treatment; Western medicine group metformin combined with desogestrel ethinyl estradiol tablets with traditional Chinese medicine treatment. The total effective rate of adenomyosis, uterine volume before and after treatment, visual analogue scale (VAS) score and menstrual flow, one-year conception rate and recurrence rate were compared between the two groups. Results The total effective rate of treatment of adenomyosis in Chinese and western medicine group was 95.24%, which was significantly higher than that in western medicine group (71.43%), the difference was statistically significant (P <0.05). There was no significant difference in uterine volume, VAS score and menstrual flow between the two groups before treatment (P> 0.05). The volume of uterus in the two groups was (132.89 ± 40.71) cm3 and the VAS score was (0.45 ± 0.19) (63.28 ± 0.86) ml, lower than that of western medicine group (152.03 ± 60.42) cm3, (2.56 ± 0.76) points and (79.88 ± 0.52) ml respectively, the difference was statistically significant (P <0.05). The 1-year conception rate of Chinese and western medicine group was 50.00%, which was significantly higher than that of western medicine group (23.81%). The 1-year recurrence rate was 2.38%, which was significantly lower than that of western medicine group (14.29%, P <0.05). Conclusions Metformin combined with ethinyl progesterone ethinyl estradiol tablets with traditional Chinese medicine prescription for the treatment of adenomyosis clinical effect is exact, can effectively improve patients with menstrual conditions and uterine volume, pain relief, improve pregnancy rate, reduce the recurrence rate, it is worth promoting.