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探讨扩张型心肌病（DCM）的心功能变化，比较多普勒组织显像（DTI）与传统心功能指标的敏感性及可靠性。方法对25例DCM患儿分别测量其心腔大小、EPSS（Epoint－septalseparation）、左室心肌重量指数（LVMI）、二大瓣血流E峰及A峰、左室射血分数（LVEF）、每搏指数（SI）及DTI测量其二尖瓣环收缩期及舒张早期运动速度（MVR－SV、MVR－DeV），在室后壁心内膜收缩期及舒张期运动速度（LVPW－EnSV、LVPW－EnDV），并设正常对照组143名。结果DCM患儿心脏收缩及舒张功能均显著下降，心肌运动速度显著降低．MVR－DeV与LVMI、EPSS是显著负相关（r=-0．84，-0．83P＜0．01），与LVEF、SI是显著正相关（r=0．844，0．77P＜0．01），同时其敏感性显著高于LVEF及SI（P＜0．05）；DTI测量心肌的舒张功能其敏感性、可靠性均高于二失瓣血流E峰与A峰，而E／A敏感性最差，且多数DCM呈假性正常，MVR－DeV与E峰、A峰及E／A均无显著直线相关性（P均＞0．05），与病情一致。结论DCM的收缩及舒张功能均显著下降，DTI指标较传统心功能指标更敏感而可靠。
To investigate the changes of cardiac function in patients with dilated cardiomyopathy (DCM) and to compare the sensitivity and reliability of DTI and traditional cardiac function. Methods Echocardiography, Epoint-septal separation (EPSS), left ventricular myocardial mass index (LVMI), E-peak and A peak of two major valves, LVEF, The systolic and diastolic velocities (LVPW-EnSV, MVR-SV and MVR-DeV) of mitral annulus and ventricular diastolic velocities LVPW-EnDV), and set the normal control group 143. Results The cardiac contractility and diastolic function of DCM children were significantly decreased, and the myocardial velocity was significantly decreased. There was a significant negative correlation between MVR-DeV and LVMI and EPSS (r = -0.84, -0.83 P <0.01). There was a significant positive correlation between MVR-DeV and LVEF and SI (r = 0.844,0.77 P < 01), while its sensitivity was significantly higher than LVEF and SI (P <0.05); DTI measurement of myocardial diastolic function of its sensitivity and reliability were higher than the two loss of blood flow E peak and A peak, and E / A had the poorest sensitivities and the majority of DCMs showed a normality. There was no significant linear correlation between MVR-DeV and E peak, A peak and E / A (all P> 0.05). Conclusion The contractile and diastolic functions of DCM are significantly decreased. The DTI index is more sensitive and reliable than the traditional cardiac function indexes.