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1.本文报告锑钾治疗家兔血吸虫病的剂量与疗程的探求。首先探求促使成虫大量向肝转移时所需有效剂量,继则探求控制成虫不能向肠复位时所需有效剂量与日程。2.锑钾每日按体重每公斤8毫克,分别注射1,2,3天,停药1天后肝内成虫检出率分别74.1%,93.5%,与98.0%。3.在锑钾每日按体重每公斤8毫克连续二日后,继以第2天锑排泄量(相当于锑钾1.62毫克/每公斤体重)的1,2,3倍,分别维持3,5,7天。结果成虫残余率与维持的剂量大小及日程长短成反比。4.根据这次动物实验结果,以锑钾每日按体重每公斤8毫克注射两天,继以维持第2天锑排泄量的三倍,连续3-5天治疗家兔血吸虫病,可以获得比较满意的结果。
1. This article reports antimony potassium treatment of rabbit schistosomiasis dose and treatment of exploration. First of all, to find the effective dose required to promote the massive transfer of adult worms to the liver, and then to explore effective doses and schedules needed to control adults when they can not be reset to the intestine. Antimony potassium daily 8 mg per kilogram of body weight, were injected 1, 2, 3 days, 1 day after stopping the detection of intrahepatic adults were 74.1%, 93.5%, and 98.0%. 3. In antimony potassium daily 8 mg per kilogram of body weight for two consecutive days, followed by the second day of antimony excretion (equivalent to 1.62 mg of antimony potassium per kilogram of body weight) 1, 2, 3 times, respectively, to maintain 3,5 ,7 days. Results The residual rate of adult worms was inversely proportional to the dose and duration of maintenance. 4. According to the results of this animal experiment, antimony potassium daily injection of 8 mg per kilogram of body weight for two days, followed by the second day to maintain the amount of antimony excretion three times for 3-5 days treatment of rabbit schistosomiasis can be obtained Satisfactory results.