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现代的药物制剂研究必须考虑药物的吸收、分布、代谢及排泄,根据临床需要的最佳治疗方案,寻找良好的给药系统。将活性药物用新剂型的方法赋予必要的物理或物理化学性质称为给药系统,主要目的是提高药物的有效性,降低不必要的过高血药浓度,适当延长体内作用时间和减少副作用等。为了发挥药物的确切效果,要求:(1)使一定量的药物以一定的速度输入循环系统,(2)
Modern drug formulation research must consider the absorption, distribution, metabolism and excretion of drugs, and find the best drug delivery system according to the best treatment plan for clinical needs. The administration of active pharmaceuticals in the form of novel dosage forms is referred to as the delivery system for the necessary physical or physico-chemical properties, the main purpose of which is to improve the effectiveness of the drug, to reduce unnecessary excessively high plasma concentrations, to appropriately prolong the duration of action in vivo and to reduce side effects . In order to exert the exact effect of the drug, it is required that (1) a certain amount of drug be input into the circulatory system at a certain speed, (2)