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目的 研究真胰岛素、胰岛素原与睡眠打鼾的关系。方法 按照随机分层抽样的原则 ,在江苏省邳州市的农村共调查 1193名 35～ 5 9岁的常住居民 ,其中男性 5 30名 ,女性 6 6 3名 ,平均年龄为 4 6 .6 9岁 ,调查其睡眠打鼾情况。应用生物素 -亲和素放大系统为基础的单克隆抗体夹心酶联免疫方法检测真胰岛素、胰岛素原。结果 Spearman相关分析及调整了年龄、性别后的协方差分析结果均显示打鼾的频率与胰岛素原的浓度及心血管危险因素的聚集呈正相关 ,调整了年龄、性别后的协方差分析结果显示 ,真胰岛素的浓度在不同的打鼾组间分布有统计学差异。调整了年龄、性别、体重指数、腰围与真胰岛素后进行的多元逐步Logistic回归分析结果显示胰岛素原是睡眠打鼾的独立危险因素。结论 心血管危险因素聚集、β细胞功能缺陷及高胰岛素原血症、睡眠呼吸障碍等互为因果、相互影响 ,可能为一种尚未被人类所认识的综合征
Objective To study the relationship between true insulin, proinsulin and sleep snoring. Methods According to the principle of random stratified sampling, a total of 1193 permanent residents 35 to 59 years old were surveyed in the rural areas of Pizhou City, Jiangsu Province, including 5,30 males and 6,63 females, with an average age of 46.69 years , Investigate their sleep snoring. Application of biotin-avidin amplification system based on monoclonal antibody sandwich enzyme-linked immunosorbent assay for true insulin, proinsulin. Results Spearman correlation analysis and adjusted for age, gender covariance analysis showed that the frequency of snoring and proinsulin concentration and cardiovascular risk factors were positively correlated, adjusted for age, gender covariance analysis showed that true Insulin concentrations were significantly different among different snoring groups. Multivariate stepwise logistic regression analysis adjusted for age, gender, body mass index, waist circumference, and true insulin showed that proinsulin was an independent risk factor for sleep-snoring. Conclusion Aggregation of cardiovascular risk factors, β-cell dysfunction and hyperinsulinism, sleep-disordered breathing and other causal interactions may be one syndrome that has not yet been recognized by human beings