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通过观察肾功能、平均动脉压、红细胞比积、肾皮质和血浆脂质过氧化物和维生素E含量、肾皮质和红细胞超氧化物歧化酶活力、肾皮质和红细胞膜钠钾ATP酶活力、肾皮质过氧化氢酶活力、单个核细胞内游离钙浓度、单个核细胞白介素-1产量、残肾形态学等指标,发现复方川芎散延缓5/6肾切除大鼠慢性肾衰进程的作用优于维生素E治疗,可能与其抗氧化、抑制系膜细胞增殖和钙阻断等机制有关。
By observing renal function, mean arterial pressure, hematocrit, renal cortex and plasma lipid peroxide and vitamin E content, renal cortex and red blood cell superoxide dismutase activity, renal cortex and erythrocyte membrane sodium potassium ATP enzyme activity, kidney Cortical catalase activity, mononuclear intracellular free calcium concentration, mononuclear cell interleukin-1 production, and residual kidney morphology were found to be superior to the compound Chuanxiong Powder in delaying the progression of chronic renal failure in 5/6 nephrectomized rats. Vitamin E treatment may be related to its anti-oxidation, inhibition of mesangial cell proliferation and calcium blocking and other mechanisms.