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[目的]观察复方益肝灵片联合水飞蓟宾防治抗结核药物肝损害疗效。[方法]使用随机平行对照方法,将78例门诊患者按就诊顺序号方法简单随机分两组。对照组47例复方益肝灵片,4片/次,3次/d。治疗组31例水飞蓟宾,70mg/次,3次/d;复方益肝灵片同对照组。连续治疗12周为1疗程。观测临床症状、ALT、AST、GGT、TBIL、不良反应。治疗1疗程,判定疗效。[结果]治疗组显效21例,有效8例,无效2例,总有效率93.55%;对照组显效13例,有效22例,无效12例,总有效率77.42%;治疗组疗效优于对照组(P<0.05)。ALT、AST两组均有改善(P<0.01),TBIL治疗组改善优于对照组(P<0.01),ALT、AST、GGT两组间无明显差异(P>0.05)。[结论]复方益肝灵片联合水飞蓟宾防治抗结核药物肝损害,疗效满意,无严重不良反应,值得推广。
[Objective] To observe the efficacy of compound Yiganling tablets and silybin in preventing and treating anti-TB drugs liver damage. [Methods] Using randomized parallel control method, 78 outpatients were randomly divided into two groups according to the sequence number of visiting doctor. The control group 47 cases of Yiganling tablets, 4 tablets / time, 3 times / d. The treatment group, 31 cases of silybin, 70mg / time, 3 times / d; compound Yiganling tablets with the control group. Continuous treatment for 12 weeks for a course of treatment. Observed clinical symptoms, ALT, AST, GGT, TBIL, adverse reactions. Treatment of a course of treatment to determine the efficacy. [Results] In the treatment group, 21 cases were markedly effective, 8 cases were effective, 2 cases were ineffective, and the total effective rate was 93.55%. In the control group, 13 cases were markedly effective, 22 cases were effective, 12 ineffective and the total effective rate was 77.42% (P <0.05). ALT, AST improved in both groups (P <0.01), TBIL treatment group improved better than the control group (P <0.01), ALT, AST, GGT no significant difference between the two groups (P> 0.05). [Conclusion] Fufang Yiganling tablet combined with silybin in prevention and treatment of anti-TB drug liver damage has satisfactory curative effect and no serious adverse reactions, which deserves promotion.