血小板激活因子（ＰＡＦ）是一种活性很强的磷脂介质，在人类生殖的各个环节，如排卵、受精、着床、分娩以及一些妊娠合并症中均发挥作用。ＰＭ通过与细胞表面特异受体结合传递跨膜信息。本文就ＰＡＦ在生殖中的作用，ＰＡＦ受体的理化特性、分子结构、信息传递机制，以及几类ＰＡＦ受体拮抗剂的作用等方面进行综述。 Platelet-activating factor (PAF) is a highly active phospholipid mediator that plays a role in various aspects of human reproduction such as ovulation, fertilization, implantation, childbirth and some complications of pregnancy. PM delivers transmembrane information by binding to cell-surface-specific receptors. In this paper, the role of PAF in reproduction, physical and chemical properties of PAF receptors, molecular structure, information transfer mechanism, and the role of several PAF receptor antagonists and other aspects are reviewed.