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转录因子红细胞系-2p45相关因子2(Nuclear factor erythroid-2p45-related factor 2,Nrf2)是细胞调节抗氧化应激反应的重要转录因子,其与抗氧化反应元件(Antioxidant response element,ARE)结合,调控第Ⅱ相解毒酶及抗氧化酶基因的表达,是机体抵抗内外氧化应激的关键保护性通路。中枢神经系统氧耗高,多不饱和脂肪酸含量丰富,对氧化应激极为敏感,Nrf2/ARE转导通路在中枢神经系统中作用的研究越来越受到重视。本文对Nrf2/ARE转导通路的调控机制及其在中枢神经系统疾病中作用的最新研究进展作一综述。
The transcription factor erythroid-2p45-related factor 2 (Nrf2) is an important transcription factor that regulates antioxidant stress response in cells. It binds to antioxidant response element (ARE) Regulating phase Ⅱ detoxification enzyme and antioxidant enzyme gene expression, is the body’s resistance to oxidative stress inside and outside the key protective pathway. Central nervous system oxygen consumption, polyunsaturated fatty acid content is extremely sensitive to oxidative stress, Nrf2 / ARE transduction pathway in the central nervous system more and more attention. This review summarizes recent advances in the regulation of Nrf2 / ARE transduction pathway and its role in central nervous system diseases.