类风湿关节炎(rheumatoid,RA)是以慢性对称性多关节炎为主要临床表现的全身性自身免疫病,多见于30~50岁的女性,男女比例约为1∶2,本病的病因及发病机制目前还不清楚。RA主要病理变化为关节滑膜组织异常增殖形成血管翳,关节局部活化的炎性细胞、滑膜成纤维细胞等产生炎症因子如TNF、IL-6、IL-17及趋化因子等,导致关节炎症及破骨活化,最终导致关节畸形、功能丧失。 Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by chronic symptomatic polyarthritis. It is more common in women aged 30 to 50 years. The ratio of male to female is about 1: 2. The etiology of this disease The pathogenesis is not yet clear. The main pathological changes of RA are the abnormal proliferation of the synovial tissue, the formation of blood vessels, inflammatory cells activated locally by joints, synovial fibroblasts and other inflammatory factors such as TNF, IL-6, IL-17 and chemokines, Inflammation and osteoclast activation, eventually leading to joint deformity, loss of function.