Background: Perimembranous ventricular septal defect combined with right coronary cusp bulge generally should be treated with surgical thoracotomy,owing to the potential aortic regurgitation.However,the minimally invasive method of transcatheter closure has always attracted the attention of cardiologists and patients.The present study aimed to apply transcatheter occlusion in treating ventricular septal defect with right coronary cusp bulge and further evaluate the clinical effect through follow-up.Materials and methods: A total of 40 children diagnosed as having a ventricular septal defect with fight coronary cusp bulge,examined using transthoracic echocardiography and cardiovascular angiography,were enrolled in this study.The ventricular septal defects were closed by placing occluders through transcatheter occlusion treatment.During the operation process,the children underwent angiography and transthoracic echocardiography examinations to check the position of the occlude and the extent of aortic regurgitation.The influence of occlusion on the conduction system was evaluated using a surface electrocardiogram.The children were followed up after their procedures.Results: All 40 patients were immediately and successfully occluded.Three patients with filament residual shunts were observed during the operations.No major surgical complications occurred during the perioperative period.During the follow-up period,the positions of all the occluders were good,the residual shunts in the three patients disappeared,and no new or aggravated aortic regurgitation occurred.Electrocardiogram did not reveal any atrioventricular blocks.Only one patient suffered from an incomplete right bundle branch block.Conclusions: Children diagnosed with ventricular septal defect combined with right coronary cusp bulge could be considered for transcatheter occlusion.With appropriate indications and methods,the effect may be favorable.