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作者报道了1983年～1987年治疗的41例原发于CNS非何杰金氏淋巴瘤(NHL)的前瞻性Ⅱ期临床研究的结果。年龄≥18岁,病理证实只侵及脑实质,脊髓造影及脑脊液细胞学检查证实无脊髓受侵,无远处受侵证据,无AIDS或AIDS相关症状,以往无恶性肿瘤病史及放、化疗史。41例中行手术活检17例,切除23例,开颅探查1例;病灶单发33例,多发8例;KPS评分70～100分21例,40～60分20例;年龄<60岁者14例,≥60岁27例。放疗用4～10MV或~(60)Co先以双侧对穿野照射全脑与全脑膜,下界于第2颈椎下缘,剂量40Gy/1.8Gy/次。
The authors report the results of a prospective phase II clinical study of 41 patients with CNS non-Hodgkin’s lymphoma (NHL) treated from 1983 to 1987. Age ≥ 18 years of age, pathology confirmed only invasion and brain parenchyma, myelography and cerebrospinal fluid cytology confirmed no spinal cord invasion, no evidence of distant invasion, no AIDS or AIDS-related symptoms, no past history of malignant tumor and radiotherapy and chemotherapy history . 41 cases of biopsy in 17 cases, 23 cases of resection, 1 case of craniotomy; 33 cases of single lesions, 8 cases of multiple; KPS score of 70 to 100 in 21 cases, 40 to 60 points in 20 cases; <60 years of age 14 Cases, ≥ 60 years old in 27 cases. Radiotherapy with 4 ~ 10MV or ~ (60) Co first to the bilateral exposure to the whole field and whole meningeal perfusion, lower bound at the lower edge of the second cervical vertebra, the dose of 40Gy / 1.8Gy / times.