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３０只健康新西兰白兔，随机分为Ａ、Ｂ两组，每组１５只。Ａ组右膝关节内注射醋酸强的松龙７．５ｍｇ／ｋｇ，每周１次；Ｂ组右膝关节内注射生理盐水０．３７５ｍｌ／ｋｇ，每周１次，每组分别于第３、５、７、９、１１周的第１天，各取３只动物，在氯胺酮麻醉下，行双侧胫骨上端、股骨下端和膝关节腔穿刺，并测定腔内压力。结果：Ａ组用药２次后，骨髓腔内压明显高于Ｂ组，且随用药次数的增加而升高，用药１０次后，胫骨内压比Ｂ组高出２倍（３５ｃｍＨ２Ｏ比１１ｃｍＨ２Ｏ）。Ｂ组在整个实验期间均无明显改变。结论：关节内注射皮质类固醇可造成骨髓腔内压升高。提示，关节内注射皮质类固醇应慎重，必要时应减少用量和延长间隔时间。
Thirty healthy New Zealand white rabbits were randomly divided into A and B groups, 15 in each group. A group of right knee joint injection of prednisolone acetate 7.5mg / kg, once a week; B group right knee joint injection of saline 0.375ml / kg, once a week, each group were 3, On the 1st, 5th, 7th, 9th, and 11th days, three animals were taken from each other. Under the anesthesia of ketamine, bilateral upper tibia, lower femur and knee joint were punctured and intraluminal pressure was measured. Results: The intramedullary pressure in group A was significantly higher than that in group B after 2 times of treatment, and increased with the increase of the number of medication. After 10 times of treatment, the tibial pressure was twice as high as that of group B (35cmH2O vs 11cmH2O). Group B did not change significantly during the whole experiment. CONCLUSIONS: Intra-articular injection of corticosteroids causes an increase in intramedullary pressure. Tip, intra-articular injection of corticosteroids should be careful, if necessary, reduce the dosage and extend the interval.