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目的 研究大鼠胃内灌注蛋白胨引起胃粘膜适应性细胞保护作用中胃粘膜血流量的变化。方法 胃内灌注高浓度和低浓度盐酸乙醇 (HCl+EtOH)以及 6 %蛋白胨溶液 ,观察胃粘膜血流量改变在胃粘膜损伤过程中的作用。结果 胃内预先灌注低浓度HCl+EtOH或 6 %蛋白胨后灌注高浓度HCl+EtOH ,胃粘膜血流量适应性增加 ,与单独灌注高浓度HCl+EtOH组相比分别增加 34.2 %和 2 6 .7% (P <0 .0 5 ) ;胃粘膜大体损伤面积比单独高浓度HCl+EtOH组减轻 46 .5 %和 37.4% (P <0 .0 1,P <0 .0 5 ) ,光镜下损伤深度比单独高浓度HCl+EtOH组减轻 41%和 35 .3 % (P <0 .0 1)。结论 胃内蛋白胨引起的胃粘膜血流量适应性增加参与胃粘膜细胞保护作用
Objective To study the changes of gastric mucosal blood flow in rat gastric perfusion peptone induced gastric mucosal adaptive cytoprotection. Methods The stomach was perfused with high concentration and low concentration hydrochloric acid ethanol (HCl + EtOH) and 6% peptone solution to observe the role of gastric mucosal blood flow changes in gastric mucosal injury. Results Gastric mucosal blood flow adaptively increased after gastric perfusion with low concentration of HCl + EtOH or 6% peptone followed by high concentration of HCl + EtOH, which increased by 34.2% and 26.7% compared with high concentration of HCl + EtOH alone % (P <0.05). The gross lesion area of gastric mucosa was reduced by 46.5% and 37.4% (P <0.01, P <0.05) The lesion depth was 41% and 35.3% lower than that of HCl + EtOH alone group (P <0.01). Conclusion Gastric peptone-induced gastric mucosal blood flow adaptation is involved in gastric mucosal cell protection