论文部分内容阅读
目的：用文献计量学方法分析抗菌药物在细胞内分布的研究进展，为选择杀死胞内寄存病原体的抗菌药物研究提供参考。方法检索自建库到2013-08 Pubmed，Embase，SCI，及CNKI数据库公开发表的文献，用EndNote软件进行整理，对其发表年份、作者、研究机构、被引频次及论著的研究内容进行计量分析。结果共纳入外文文献901篇，中文文献14篇。文献类型以论著（548篇）为主，其次为综述（175篇）；被引频次最高为131次；多数文献为抗菌药物治疗感染及胞内细菌耐药机制研究方面的文章。结论抗菌药物在细胞内分布的研究日益受到全球的广泛关注，研究内容愈加深入。“,”Objective To analyze the recent progress on intracellular an-timicrobial agents distribution over the past 50 years with bibliometric ap-proach , and to provide reference for study on choosing of antimicrobial a-gents to kill intracellular hosting pathogens.Methods Literatures were searched in Pubmed , Embase , Science Citation Index , and CNKI data-bases from beginning to August 2013.EndNote 7.0 was used to sort these articles and the bibliometric analysis was carried out in respect of published years , author , research institutions , cited frequency , and re-search contents etc.Results A total of 915 papers were collected in our research, including 901 foreign papers and 14 Chinese papers.Among 915 papers, there were 548 piece of original articles , and 175 piece of reviews;the most frequently cited paper was cited for 131 times.Major of those papers were focused on antimicrobial agents treatment for infec-tions and intracellular bacterial resistance mechanisms.Conclusion Researches on intracellular antimicrobial agents distribution have drawn great attention around the world and have been deeper in recent 20 years.