全身热疔作为全身性肿瘤辅助治疗的手段之一越来越受到广泛的关注,已成为继手术、化疗、放疗和生物治疗之后的第5大全身治疗手段。近年来,出现了大量关于全身热疗在恶性肿瘤治疗中应用的研究,其中一些已进入了Ⅲ期临床试验。现就全身热疗的概念、加温方法、作用机制、适应范围和临床研究成果等作一综述。 As one of the means of systemic adjuvant therapy, systemic hyperthermia has drawn more and more attention and has become the fifth largest systemic treatment after surgery, chemotherapy, radiotherapy and biotherapy. In recent years, there has been a lot of research on the application of systemic hyperthermia in the treatment of malignant tumors, some of which have entered Phase III clinical trials. Now on the concept of whole body hyperthermia, heating methods, mechanism of action, the scope of adaptation and clinical research results are reviewed.