论文部分内容阅读
为了解早产儿接种百日咳无细胞菌苗DTP和乙型肝炎(DTaP-HB)四联疫苗后能否产生较好的抗体应答,作者选择了34名早产儿[孕龄(GA)25～35周]和28名足月儿(GA 38～42周),分别在 3、5、11月龄时接种由SmithKline Beecham公司制造的DTaP-HB四联疫苗.每剂四联疫苗含百日咳类毒素(PT)25μg、丝状血凝素(FHA)25μg、69kDa蛋白8μg、白喉类毒素(DT)25Lf、破伤风类毒素(TT)10Lf和乙型肝炎表面抗原(HBsAg)10μg.免疫后8天内逐日记录临床症状,于第2针和第3针后5～6周采血,观察血清学应答.
To understand whether preterm infants can develop better antibody responses after inoculation of the tetanus toxoid vaccine (DTP) and hepatitis B virus (DTaP-HB), the authors selected 34 preterm infants (gestational age (GA) 25-35 weeks ] And 28 full-term infants (GA 38-42 weeks) were vaccinated with the DTaP-HB Tetra Vaccine manufactured by SmithKline Beecham at 3, 5, and 11 months of age Each dose of the quadruple vaccine contained pertussis toxoid (PT ), 25 μg of FHA, 8 μg of 69 kDa protein, 25 Lf of DT, 10 Lf of TT and 10 μg of hepatitis B surface antigen (HBsAg) Clinical symptoms: blood was collected 5 to 6 weeks after the second and third needles, and the serological response was observed.