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目的探讨苦参素预防干预治疗肿瘤化疗引起的白细胞减少及肝功能损伤疗效。方法对正常执行全身化疗或灌注化疗的150例恶性肿瘤患者,在化疗前和化疗执行的同时,静脉滴注苦参素,每日2次,每次100ml,14~28d为1疗程,观察化疗前后白细胞减少、肝功能损伤(异常)、生存质量副反应情况,并与对照组140例未作干预治疗的化疗病人比较分析。结果治疗组150例中,化疗后新增白细胞减少Ⅰ~Ⅱ°33例(22.00%),Ⅲ~Ⅳ°11例(7.33%),肝功损伤(新增或加重)14例(9.33%)。Kps评分下降20例(13.33%),提高90例(60.00%)。相关毒副反应只有3例(2.00%)为轻度皮炎;对照组140例中,化疗后白细胞减少Ⅰ~Ⅱ°63例(45.00%),Ⅲ~Ⅳ°21例(15.00%),肝功损伤(新增或加重)32例(22.86%)。Kps评分下降48例(34.29%),提高仅18例(12.86%),两者分别比较,P均<0.05。结论苦参素干预治疗肿瘤化疗引起的白细胞减少及肝功能损伤有显著疗效,同时能提高生存质量,未发现严重的毒副反应。
Objective To investigate the effect of oxymatrine on the prevention and treatment of neutropenia and liver damage induced by chemotherapy. Methods 150 cases of malignant tumor patients who underwent systemic chemotherapy or infusion chemotherapy were treated with intravenous drip of matrine twice a day for 100ml every 14 to 28 days before chemotherapy and chemotherapy. Leukopenia, liver dysfunction (abnormal), quality of life side effects, and compared with the control group of 140 patients without intervention treatment of chemotherapy patients were compared. Results Among the 150 patients in the treatment group, 33 cases (22.00%) of leukopenia, 11 cases (Ⅲ.3 °) of Ⅲ ~ Ⅳ ° and 14 cases (9.33%) of liver injury (new or exacerbated) . Kps score decreased in 20 cases (13.33%), increased 90 cases (60.00%). Only 3 cases (2.00%) had mild dermatitis. Among the 140 cases in the control group, leukopenia in Ⅰ-Ⅱ ° group (45.00%), 21 cases (Ⅲ) Injury (new or increased) in 32 cases (22.86%). Kps score decreased in 48 cases (34.29%), an increase of only 18 cases (12.86%), the two were compared, P <0.05. Conclusion Oxymatrine intervention in the treatment of chemotherapy-induced neutropenia and liver damage have a significant effect, and can improve the quality of life, did not find serious side effects.