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目的探讨化疗放疗联合方案对小细胞肺癌脑转移患者的治疗效果。方法将87例小细胞肺癌脑转移患者随机分为两组,单纯放疗组43例(A组);化疗及脑部放疗组44例(B组),采用同步放化疗方法。结果就脑内转移灶而言,A组中完全缓解(CR)2例,部分缓解(PR)21例,疾病稳定(SD)18例,疾病进展(PD)2例,颅内病灶治疗有效(CR+PR)率(RR)为53.5%(23/43),疾病控制(CR+PR+SD)率为95.3%(41/43)。B组中CR 8例,PR 19例,SD 16例,PD 1例,颅内病灶治疗有效(CR+PR)率为61.4%(27/44),疾病控制(CR+PR+SD)率为97.7%(43/44)。B组CR、SD及RR显著高于A组,PD则显著低于A组。结论化疗放疗联合方案可显著提高小细胞肺癌脑转移患者的治疗效果。
Objective To investigate the therapeutic effect of combined chemotherapy and radiotherapy on patients with brain metastases from small cell lung cancer. Methods Eighty-seven patients with brain metastases from small cell lung cancer were randomly divided into two groups, 43 patients in the radiotherapy group (group A) and 44 patients in the chemotherapy and brain radiotherapy group (group B). Results For intracranial metastases, there were 2 cases of complete remission (CR) in group A, 21 cases of partial remission (PR), 18 cases of stable disease (SD), 2 cases of disease progression (PD) and effective treatment of intracranial lesions The rate of CR + PR was 53.5% (23/43) and the rate of disease control (CR + PR + SD) was 95.3% (41/43). There were 8 cases in CR group, 19 cases in PR group, 16 cases in SD group and 1 case in PD group. The effective rate of CR + PR in group B was 61.4% (27/44) and the rate of CR + PR + SD was 97.7% (43/44). The CR, SD and RR in group B were significantly higher than those in group A, and PD were significantly lower than those in group A. Conclusion Combined chemotherapy and radiotherapy can significantly improve the therapeutic effect of patients with brain metastases from small cell lung cancer.