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目的探讨在核事故发生后,18F-FDG摄取值能否作为一种剂量学标准来方便、快速、准确地评估个体辐射剂量。方法 48只西藏迷你猪随机分为对照组(n=3)和实验组(n=45),实验组在全身照射前注入18F-FDG,分别于6、24和72h后接受全身照射,照射剂量为1～11Gy。收集脾及血液样本进行组织学、细胞凋亡和血液分析研究。结果实验组和对照组的脾平均标准摄取值(SUV)存在显著差异。照射后6h,实验组脾SUV与辐射剂量呈显著相关,Spearman相关系数为0.97(P<0.01)。组织学观察表明,脾淋巴细胞损伤程度与辐射剂量呈正相关。细胞凋亡是脾淋巴细胞死亡的主要方式,与流式细胞仪分析结果相同。结论在西藏迷你猪实验模型中,辐射剂量与脾对18F-FDG摄取值密切相关。这一发现表明,18F-FDGPET/CT扫描可用于个人辐射剂量的快速检测。要点①脾是对全身照射反应敏感的器官。②在西藏迷你猪,辐射剂量与脾18F-FDG摄取值密切相关。③18F-FDGPET/CT可能对于个体辐射剂量的预测具有重要作用。
Objective To investigate whether 18F-FDG uptake value can be used as a dosimetric criterion to evaluate individual radiation dose easily, rapidly and accurately after a nuclear accident. Methods 48 miniature Tibetan pigs were randomly divided into control group (n = 3) and experimental group (n = 45). The experimental group was injected with 18F-FDG before the whole body irradiation and received whole body irradiation at 6, 24 and 72 hours respectively. For 1 ~ 11Gy. Spleen and blood samples were collected for histology, apoptosis and blood analysis. Results There was a significant difference in spleen average standard intake (SUV) between the experimental group and the control group. Six hours after irradiation, there was a significant correlation between spleen SUV and radiation dose in the experimental group, Spearman’s correlation coefficient was 0.97 (P <0.01). Histological observation showed that the degree of splenic lymphocyte injury and radiation dose was positively correlated. Apoptosis is the main way of spleen lymphocyte death, the same as the results of flow cytometry. Conclusion In the mini-pig experimental model in Tibet, the radiation dose is closely related to the uptake of 18F-FDG by the spleen. This finding suggests that the 18F-FDG PET / CT scan can be used for the rapid detection of individual radiation doses. Points ① Spleen is a sensitive organ to whole body irradiation. ② in mini-pigs in Tibet, radiation dose and spleen 18F-FDG uptake value is closely related. ③18F-FDG PET / CT may play an important role in the prediction of individual radiation dose.