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目的 :观察国产坎地沙坦酯对原发性高血压 (EH)患者治疗的有效性、安全性及耐受性。方法 :EH患者 37例 ,整个研究过程包括 2周停药观察期和 8周治疗期。口服坎地沙坦酯 8mg ,qd ,在治疗 1、2、4、6和 8周末各随访 1次。服药 4周后若患者坐位舒张压 (DBP)≥ 90mmHg(1mmHg =0 .133kPa)则增加剂量至 16mg。在治疗开始时以及治疗期的第 8周进行 2 4h动态血压监测。结果 :①服药后 2 4h和白昼、夜间收缩压 (SBP)和DBP较服药前明显下降 ,分别为 (7.5 4± 12 .2 9) / (5 .19± 8.2 8) ,(6 .99± 14 .0 5 ) / (4 .6 2± 9.5 0 ) ,(8.4 8± 13.4 0 /(6 .0 2± 9.5 0 )mmHg ,均 P <0 .0 1。② 2 4h动态血压监测示服药后 2 4h各时点DBP和SBP均较服药前下降 ,大部分时点P <0 .0 5。③DBP、SBP的谷峰比率分别为 0 .70、0 .6 4。④平滑指数 (SI) :SBP、DBPSI分别为 3.99、3.10。⑤轻微不良反应发生率为 8.1% (3/ 37例 )。结论 :患者每日一次口服国产坎地沙坦酯 8～ 16mg治疗EH能持续 2 4h安全、平稳降压
Objective: To observe the efficacy, safety and tolerability of domestic candesartan cilexetil in patients with essential hypertension (EH). Methods: EH patients in 37 cases, the entire study process including two weeks withdrawal observation period and eight weeks treatment period. Candesartan cilexetil 8mg, qd, in the treatment of 1, 2, 4, 6 and 8 weeks each followed up 1 time. After 4 weeks of treatment, if the patient’s DBP ≥ 90mmHg (1mmHg = 0.133kPa) increase the dose to 16mg. At the beginning of treatment and the 8th week of treatment, 24-hour ambulatory blood pressure monitoring was performed. Results: ①The systolic blood pressure (SBP) and DBP decreased significantly at 24 h, day and night, and were (7.5 4 ± 12.29) / (5.19 ± 8.2 8) and (6.99 ± 14 .0 5) / (4.6 ± 9.5 0), (8.4 8 ± 13.4 0 / (6 .0 2 ± 9.5 0) mmHg, all P <0 .0 1.②24h ambulatory blood pressure monitoring showed medication DBP and SBP decreased at all time points after 24 h, P <0.05 at most time points. The peak-to-valley ratios of DBP and SBP were 0.70, 0.64 and 4. The smoothness index (SI) : SBP and DBPSI were 3.99 and 3.10, respectively.⑤The incidence of mild adverse reactions was 8.1% (3/37) .Conclusion: The daily oral administration of candesartan cilexetil 8-16mg in patients with EH can maintain a safe 24 hours, Steady buck