目的:探讨茵栀黄注射液对刀豆素A(ConA)诱导的小鼠急性肝损伤的影响。方法:采用刀豆素蛋白诱导小鼠免疫性肝损伤,检测小鼠血清丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)活性和总胆红素(TBIL)含量,测定肝脏指数,HE染色观察肝组织病理变化。结果:茵栀黄注射液各剂量组均可明显降低ALT、AST活性;明显改善肝细胞组织坏死损伤;其中高、中剂量组均可明显降低肝脏指数。结论:茵栀黄注射液对ConA诱导的小鼠免疫性肝损伤具有保护作用。 Objective: To investigate the effect of Yinzhihuang injection on acute liver injury induced by ConA in mice. Methods: Immunohistochemical liver injury was induced by concanavalin, and serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) activity and total bilirubin (TBIL) levels were measured. Liver index was measured and hepatic pathological changes were observed by HE staining. Results: Yinzhihuang injection can significantly reduce the activity of ALT and AST in all dose groups, and significantly improve the tissue necrosis of liver cells. The high and middle dose groups can significantly reduce the liver index. Conclusion: Yinzhihuang injection has protective effect on ConA-induced immune liver injury in mice.