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５羟色胺—多巴胺平衡拮抗剂概念的发展ＭａｔｉＨｕｔｕｎｅｎ在精神分裂症的多巴胺假说确立以前，５羟色胺（５—ＨＴ）假说广为流传。该假说建立在麦角二乙酰胺的致幻作用和精神分裂症患者的异常５羟色胺水平的基础上。在发现抗精神病药氯氮平不仅是多巴胺Ｄ２受体拮抗...
5 Development of the Concept of Serotonin-Dopamine Balance Antagonists MatiHutunen The serotonin (5-HT) hypothesis is widely circulated until the dopamine hypothesis of schizophrenia has been established. This hypothesis builds on the hallucinogenic effects of ergodamine and the abnormal serotonin levels in schizophrenia patients. In the discovery that antipsychotics clozapine is not only dopamine D2 receptor antagonist ...