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本文报告一种新型的 H_2受体拮抗剂 Ranitidin,其分子中不含有组氨酸的咪唑核,后者曾认为是阻断 H_2受体所必需的基团。对15例活动性十二指肠溃疡患者进行试验,共分两组。其中7例于中午6时进半流汁,当晚8时45分插鼻胃管,抽空胃内容物后,持续吸引收集每小时的胃液,共12小时。或于下午7时45分服 Ranitidin 80毫克,向右侧位休息一小时,其余试验步骤同上。其余8例将十二指肠管插至蔡氏勒带处,并置鼻胃管吸引胃内容物。每例在不同的两天内分别进
This article reports a novel H 2 receptor antagonist, Ranitidin, which contains no histidine imidazole nucleus in the molecule, the latter considered to be necessary for H 2 receptor blockade. 15 patients with active duodenal ulcer patients were divided into two groups. Among them, 7 patients poured half-juice at 6:00 in the evening and inserted nasogastric tube at 8:45 that night. After evacuating the contents of the stomach, they continued to attract and collect the gastric juice for an hour for 12 hours. Or taking Ranitidin 80 mg at 7:45 pm and taking a one-hour rest to the right, the rest of the test steps are the same as above. The remaining 8 cases of duodenal tube inserted to the Cholesterol band, and nasogastric tube to attract stomach contents. Each case in a different two days into